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And you make B12 in your gut

The most common background oral antidiabetic drugs used at baseline were metformin (60%), sulfonylureas (29%) and DPP 4 inhibitors (12%)

Nutrient signals like glucose and fats, as well as hormonal signals including glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2), Peptide YY (PYY), ghrelin, cholecystokinin (CCK), and bile acids, enter the central nervous system (CNS) through the bloodstream or the vagus nerve

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Byrd Linda S